PLATOX, a 24-month project, proposes a tiered approach to address the existing toxicological data gaps for graphene family nanomaterials (GFN). GFN are part of the group of carbon based synthetic nanomaterials that are currently subject of studies to accelerate their toxicological characterization. Based on the existing toxicological information, a very high toxic potential is not expected, however, the characterization is presently incomplete and should be expanded to facilitate a proper risk assessment.

At the beginning a selection of compounds (commercially available/from partner lab) was specified (WP1). A subsequent in vitro screening including cytotoxicity and genotoxicity endpoints was done in order to identify the GFN members with the highest/lowest toxic impact on in vitro cell systems (WP2). To validate the in vitro results and to supplement the existing in vivo data on graphenes a 28-day inhalation toxicity test will be performed including an evaluation of inflammatory, genotoxic and histopathological endpoints (WP3). The last step of the project consists of evaluation of results and performance of graphene-specific risk assessment analysis (WP4).

Dissemination and Training

· 53rd Congress of the European Societies of Toxicology (EUROTOX), 10-13 September 2017, Bratislava, Slovakia, DOI 10.1016/j.toxlet.2017.07.410

· EuroNanoForum 2017, 21-23 June 2017, Valletta, Malta (Program)

· Annual meeting, 24 January 2017, Aveiro, Portugal

· 52nd Congress of the European Societies in Toxicology (EUROTOX), 4-7 September 2016, Seville, Spain (Toxicology Letters, 2016, 258 (S16): S261)

· PLATOX training at Fraunhofer ITEM facilities, 27 August-2 September 2016, Hannover, Germany

· Training "In silico modelling and tools under REACH" 20 May 2016, Cluj-Napoca, Romania (Program)

· National Congress of Farmacy Students from Romania, 30 March-3 April 2016, Craiova, Romania (link)

· Kick-off meeting, 15 January 2016, Hannover, Germany



PLATOX Dissemination Handbook

Experimental Design Application

Deliverable Report 4.1 | Deliverable Report 4.2

PLATOX Progress Report Year I


Raport intermediar I | Raport intermediar II (ro)

 PLATOX FINAL Progress Report

Deliverable Report 5.1 | Deliverable Report 5.2

Raport stiintific final (ro)

© 2016-2017 BIOTOX SRL | |







FP7 ERA-NET on Nanosafety Safe Implementation of Innovative Nanoscience and Nanotechnology (SIINN)

In vitro and in vivo investigations to generate validated toxicity data of graphene nanoplatelets vs a carbon black reference